Dimethyl Sulfoxide
Apexbio Technology LLC Prednisolone 50-24-8 10mM (in 1mL DMSO)
Prednisolone is a synthetic glucocorticoid structurally derived from cortisol characterized by anti-inflammatory and immunosuppressive properties Through binding to intracellular glucocorticoid receptors prednisolone modulates gene expression leading to inhibition of pro-inflammatory cytokine production suppression of immune cell proliferation and attenuation of inflammatory mediators In biomedical research prednisolone is commonly employed to investigate inflammatory pathways autoimmune responses and immune regulation mechanisms Additionally it serves as a reference compound in the screening and evaluation of novel anti-inflammatory and immunomodulatory therapeutics
Apexbio Technology LLC BIX 02565 1311367-27-7 10mM (in 1mL DMSO)
BIX 02565 (CAS 1311367-27-7) is a potent inhibitor of ribosomal S6 kinase 2 (RSK2) showing an IC50 of approximately 1 nM RSK activation typically stimulates Na /H exchanger (NHE) crucial for early cellular stress responses involving intracellular pH regulation calcium handling and potential induction of cardiac hypertrophy BIX 02565 also inhibits adrenergic ( 1A 1B 1D 2A 2) imidazoline I2 LRRK2 and PKD1 receptors at varying potencies (IC50 0 052 1 820 M 16 nM and 35 nM respectively) In vivo studies in rats demonstrated dose-dependent decreases in heart rate and mean arterial pressure This compound aids research into signaling pathways relevant to cardiovascular disorders and kinase biology
Apexbio Technology LLC Gemfibrozil 25812-30-0 10mM (in 1mL DMSO)
Gemfibrozil is a small-molecule pharmacological agent that functions primarily through activation of the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR ) By modulating PPAR signaling pathways gemfibrozil regulates lipid metabolism influencing the transcription of genes associated with fatty acid oxidation and lipoprotein synthesis resulting in reduced triglyceride levels and altered lipoprotein profiles In biomedical research contexts gemfibrozil is utilized to explore molecular mechanisms underlying lipid metabolic processes atherosclerosis progression and related metabolic disorders Furthermore gemfibrozil serves as a useful experimental tool to dissect PPAR -dependent pathways and to investigate therapeutic potentials targeting lipid abnormalities and cardiovascular disease
Apexbio Technology LLC Vidarabine 5536-17-4 10mM (in 1mL DMSO)
Vidarabine is an antiviral nucleoside analog widely studied for inhibiting replication of herpes simplex virus (HSV) and varicella-zoster virus (VZV) Structurally vidarabine is an adenine arabinoside analog that interferes with viral DNA synthesis via competitive inhibition of viral DNA polymerase resulting in chain termination In vitro studies demonstrate antiviral activity against HSV type 1 and type 2 with IC50 values typically ranging approximately from 0 1 to 1 0 M depending on experimental conditions and viral strains Vidarabine is commonly used in biomedical laboratories for investigating viral replication mechanisms screening for antiviral candidates and elucidating nucleoside analog resistance patterns
Apexbio Technology LLC Rifapentine 61379-65-5 10mM (in 1mL DMSO)
Rifapentine is an antibiotic compound employed in the treatment of pulmonary tuberculosis an infectious disease primarily caused by Mycobacterium tuberculosis Rifapentine inhibits bacterial RNA polymerase thereby preventing RNA synthesis essential for bacterial replication and survival In vitro studies demonstrate that rifapentine possesses potent activity against intracellular M tuberculosis residing within human macrophages with reported MIC values ranging from 0 015 to 0 06 mg/ml Preclinical research indicates rifapentine accumulates extensively in host cells achieving higher intracellular concentrations than structurally related rifampin Clinically rifapentine administration schedules involve twice-weekly doses during the intensive phase of tuberculosis therapy followed by weekly dosing in the continuation phase Rifapentine is commonly investigated in pharmacological studies to assess efficacy and optimize dosing regimens in pulmonary tuberculosis treatment
Apexbio Technology LLC AZD8931 (Sapitinib) 848942-61-0 10mM (in 1mL DMSO)
AZD8931 (Sapitinib CAS 848942-61-0) is a reversible small-molecule inhibitor that targets EGFR (HER1) HER2 (erbB2) and HER3 (erbB3) with similar potency It suppresses receptor phosphorylation with IC50 values of 4 nM (EGFR) 3 nM (HER2) and 4 nM (HER3) Preclinical studies using HER2-non-amplified inflammatory breast cancer (IBC) cell lines demonstrate reduced tumor cell proliferation and increased apoptosis upon AZD8931 administration In mouse xenograft models AZD8931 alone or combined with paclitaxel significantly delays tumor growth AZD8931 is under clinical evaluation as combination therapy in advanced breast cancer
Medchemexpress LLC Bay-9835 10Mm Dmso Reconst 1Ml | HY-162284-10MM-DMSO-RECON
Bay-9835 10Mm Dmso Reconst 1Ml
Apexbio Technology LLC Riluzole 1744-22-5 10mM (in 1mL DMSO)
Riluzole (CAS 1744-22-5) is a small molecule modulator of glutamatergic neurotransmission exhibiting multiple mechanisms of neuroprotection Its action primarily involves inhibition of voltage-gated sodium channels modulation of high-voltage-activated calcium and potassium channels and interference with protein kinase C activity collectively mitigating neuronal excitotoxicity In cultured rat cortical neurons riluzole inhibits inward sodium currents with an IC50 of 51 M At submicromolar to micromolar concentrations riluzole enhances sodium-dependent glutamate uptake mediated by the GLAST GLT1 and EAAC1 transporters Owing to these properties riluzole is commonly utilized in neuroscience research on excitotoxicity neurodegeneration and related pathologies
Apexbio Technology LLC Tigecycline 220620-09-7 10mM (in 1mL DMSO)
Tigecycline is a glycylcycline-class antibiotic developed as a structural derivative of tetracycline antibiotics It exerts antimicrobial activity by reversibly binding to the bacterial 30S ribosomal subunit leading to inhibition of protein synthesis Tigecycline demonstrates bacterial growth inhibition in both Gram-positive and Gram-negative pathogens including multidrug-resistant strains In vitro studies showed minimal inhibitory concentration (MIC90) values ranging between 0 12-0 5 g/ml against vancomycin-sensitive and resistant Enterococcus faecalis and Enterococcus faecium In animal infection models using MRSA strains Tigecycline displays in vivo efficacy with an ED50 approximately 0 72 mg/kg This antibiotic is commonly employed in research studies focusing on resistant bacterial infections such as complicated skin infections and intra-abdominal infections
Apexbio Technology LLC Ferrostatin-1 (Fer-1) 347174-05-4 10mM (in 1mL DMSO)
Ferrostatin-1 (Fer-1) is a selective inhibitor of ferroptosis a regulated form of iron-dependent oxidative cell death characterized by lipid peroxidation It functions primarily by reducing lipid reactive oxygen species (ROS) thus inhibiting membrane lipid peroxidation and preventing ferroptosis induction triggered by compounds such as erastin In experimental contexts Fer-1 is employed to investigate ferroptotic pathways in different disease models including cancer biology neurodegeneration and ischemic injury Ferrostatin-1 demonstrates an IC50 value of approximately 60 nM in inhibiting ferroptosis induced by erastin in cellular assays rendering it suitable for mechanistic studies and therapeutic research involving modulation of iron-dependent oxidative damage pathways
Apexbio Technology LLC Mesna 19767-45-4 10mM (in 1mL DMSO)
Mesna chemically classified as a sulfhydryl-containing compound functions primarily as a protective adjuvant during chemotherapy with oxazaphosphorine agents (such as cyclophosphamide and ifosfamide) Its mode of action involves direct binding and detoxification of urotoxic metabolites notably acrolein thereby facilitating their conversion into stable non-toxic derivatives and mitigating associated bladder toxicity Due to this detoxifying effect Mesna is widely utilized in oncology research and clinical studies investigating chemotherapy-induced urotoxicity prevention Additionally given its structural feature as a thiol donor Mesna finds applications in experimental studies exploring its antioxidant activity and potential cytoprotective effects
Apexbio Technology LLC Olmesartan 144689-24-7 10mM (in 1mL DMSO)
Olmesartan (CAS 144689-24-7) is a small molecule angiotensin II receptor antagonist primarily acting by selectively blocking the binding of angiotensin II to AT1 receptors This mechanism interrupts angiotensin II-mediated vasoconstriction and aldosterone secretion resulting in antihypertensive effects In biomedical research Olmesartan serves as a valuable tool for examining hypertensive disease models elucidating angiotensin II signaling pathways and exploring therapeutic strategies targeting cardiovascular regulation
Apexbio Technology LLC GDC-0068 (RG7440) 1001264-89-6 10mM (in 1mL DMSO)
GDC-0068 (RG7440 CAS number 1001264-89-6) is a selective small-molecule inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 It inhibits Akt activity with IC50 values of 5 nM 18 nM and 8 nM for Akt1 Akt2 and Akt3 respectively Akt signaling within the PI3K-Akt pathway regulates cellular proliferation survival and tumorigenesis and is frequently dysregulated in cancers harboring mutations in PTEN or PI3K GDC-0068 binds to and inhibits Akt activation resulting in reduced tumor cell proliferation cell-cycle arrest and induction of apoptosis supporting its utility in oncology research
Apexbio Technology LLC SP 600125 129-56-6 10mM (in 1mL DMSO)
SP 600125 (CAS 129-56-6) is a selective reversible ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK) with reported IC50 values of 40 nM for JNK1 and JNK2 and 90 nM for JNK3 Initially identified via GST-c-Jun substrate and recombinant human JNK2 screening assays SP 600125 demonstrates marked specificity being approximately 300-fold more selective toward JNK isoforms compared to ERK1 and p38-2 kinases In cellular assays SP 600125 effectively suppresses JNK-mediated phosphorylation of c-Jun and attenuates expression of IL-2 IFN- and TNF- It is widely utilized in inflammation and signal transduction research
Apexbio Technology LLC PP 1 172889-26-8 10mM (in 1mL DMSO)
PP 1 (CAS 172889-26-8) is a selective inhibitor targeting the Src family of non-receptor protein tyrosine kinases including p56lck and p59fynT (IC50 5 nM and 6 nM respectively) Src kinases regulate signal transduction pathways influencing cell proliferation migration adhesion and survival making them important targets in cancer studies In vitro PP 1 selectively suppresses Lyn kinase in RBL-2H3 cells without affecting Syk kinase and effectively inhibits RET oncogene-driven transformation at nanomolar concentrations In vivo PP 1 reduces tyrosine phosphorylation events and T-cell proliferation highlighting its utility in research on Src kinase function and signaling pathways in oncology and immunology